Genecast FOCUS - Genecast Group Inc.

Genecast FOCUS

Product Detais

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How it works

Genecast Focus is a clinically validated, NMPA approved and CE-IVD certified targeted NGS assay designed for 10+ solid tumor profiling. It offers comprehensive detection of key biomarkers across 41 driver genes and MSI status, supporting personalized treatment decisions in oncology.

SNV, Indel, CNV and MSI are detected from FFPE DNA, while fusion and rearrangement are detected from FFPE RNA. The kit accurately and rapidly provides patients with mutation information relevant to targeted drugs, immunotherapy drugs and Lynch syndrome screening.

Cancer types

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Specifications

Enrichment Method	Amplicon
Panel Design	41 genes + MSI
Sequencing Platforms	DNBSEQ-E25/DNBSEQ-G99/DNBSEQ-G400/MiniSeq/MiSeq/NextSeq 550
Package	24 tests/kit	48 tests/kit
Catalog Number	ZYCE-00302	ZYCE-00301

Applications

Precise matching for targeted therapy

Simplifies the screening process for targeted therapy and accelerates clinical decision-making. By detecting mutations, amplifications, or fusions in common driver genes (e.g., EGFR, KRAS, BRAF, ALK, ROS1), the test helps clinicians determine whether a patient is suitable for targeted treatment.

Identification of potential beneficiaries of immunotherapy

Supports assessment of immunotherapy indications, particularly for patients with MSI-H or mutations in POLE/POLD1.

Assistance in Lynch syndrome screening

Somatic MSI testing is useful for the initial screening of Lynch syndrome, and positive results warrant further germline testing.

Sample Specifications

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Type	Requirements	Sample Quantity
Surgical/Large Biopsy Tissue Sections	Area ≥ 0.5 cm², Thickness 5-10 μm; Tumor cell content ≥ 20%; Storage period ≤ 3 years.	≥ 10 unstained slides/Wax rolls with 4 slices
Small Biopsy Tissue Sections	Area ≤ 0.5 cm², Thickness 5-10 μm; Tumor cell content ≥20%; Storage period ≤ 3 years.	≥ 12 unstained slides/Wax rolls with 6 slices

In Summary

Target NCCN recommended tier I hotspot mutations in 41 genes plus MSI

Dual analysis of DNA (SNV/InDel/CNV/MSI) + RNA (Fusion) from tumor tissue

Automated workflow, from sample to report within 24 hr

Sample-efficient with minimal input and low data requirement