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Genecast OncoDuo Prime
Background

Cancer treatment has evolved from traditional chemotherapy and radiation to the era of personalized or precision medicine. In this journey, diagnosis leads the way: genetic testing now plays a key role in guiding personalized treatment. It helps determine tumor subtypes, informs treatment selection, assesses hereditary risk, and predicts prognosis and recurrence.


NGS enables comprehensive testing in a single run. It is especially useful when tissue samples are limited or when complex mutations are involved, and today it is widely adopted in clinical practice.



How it works

Genecast OncoDuo Prime is a precision therapy test for patients with 20+ solid tumor types. It combines DNA and RNA-based NGS to detect 4 major genomic alterations—SNV, InDel, CNV, and fusions—providing information to guide treatment selection and prognosis.


The test also includes MSI analysis, offering evidence to support the use of immune checkpoint inhibitors and enabling more comprehensive, personalized cancer care.


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Specifications

Enrichment MethodHybrid capture
Panel Design219 genes + MSI, DNA 188 genes + RNA 52 genes
Sequencing PlatformsDNBSEQ-G99/DNBSEQ-G400/DNBSEQ-T7/NextSeq 550/NovaSeq6000
Package24 tests/kit
Catalog NumberZYFR-02001
Applications

Therapy Selection

Guiding treatment decisions for targeted therapy, immunotherapy, and chemotherapy.

Prognosis/Diagnosis

Assisting in prognosis assessment and providing diagnostic information.

Supports (Neo)Adjuvant and Systemic Therapy Decisions

Detects SNVs, CNVs, and InDels across 188 genes at the DNA level, and 52 clinically relevant fusions at the RNA level, enabling personalized treatment planning for both adjuvant and systemic settings.

Sample Specifications


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TypeRequirementsSample Quantity
Surgical/Large Biopsy Tissue SectionsArea ≥ 0.5 cm2, Thickness 5-10 μm; Tumor cell content ≥ 10%;
Storage period ≤ 3 years.
≥ 10 unstained slides/Wax rolls with 4 slices
Small Biopsy Tissue SectionsArea ≤ 0.5 cm2, Thickness 5-10 μm; Tumor cell content ≥10%;
Storage period ≤ 3 years.
≥ 15 unstained slides/Wax rolls with 6 slices
In Summary

DNA+RNA dual-assay

Target 219 clinical actionable genes and MSI

Assay success rate >95%; accuracy >99%

Compatible with MGI and Illumina sequencing platforms

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